Newly Identified Antibacterial Compounds Are Topoisomerase Poisons in African Trypanosomes
نویسندگان
چکیده
منابع مشابه
Newly identified antibacterial compounds are topoisomerase poisons in African trypanosomes.
Human African trypanosomiasis, caused by the Trypanosoma brucei protozoan parasite, is fatal when left untreated. Current therapies are antiquated, and there is a need for new pharmacologic agents against T. brucei targets that have no human ortholog. Trypanosomes have a single mitochondrion with a unique mitochondrial DNA, known as kinetoplast DNA (kDNA), a topologically complex network that c...
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African trypanosomes are ancient eukaryotes that cause lethal disease in humans and cattle. Available drugs are inadequate and the need for new therapeutic targets is great. Trypanosoma brucei and related pathogens differ strikingly from higher eukaryotes in many aspects of nucleic acid structure and metabolism. We find yet another example of this in their unusual DNA topoisomerase IB. Type IB ...
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Parasites have developed clt~\'et tricks to evade the deadly immune detense o( d~eu mammalian hosts. Rep.ularly chanting surface coats, that is, anti~enic variation, is one ot the most appealing ~f these trick>. \Vhat ((ruld Be simpler and more effect~\c than t~ fool the immune system ol the host b b regularly changing sudacc al~t igens tllOtt' rapidly thm~ new antibodies can bc made? But m pra...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2010
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01025-09